Lucia Carmela Cosenza Selected Research

Fetal Hemoglobin (Hemoglobin F)

1/2022	Expression of γ-globin genes in β-thalassemia patients treated with sirolimus: results from a pilot clinical trial (Sirthalaclin).
12/2021	Treatment of Erythroid Precursor Cells from β-Thalassemia Patients with Cinchona Alkaloids: Induction of Fetal Hemoglobin Production.
10/2020	Discovery of Novel Fetal Hemoglobin Inducers through Small Chemical Library Screening.
11/2019	Surface plasmon resonance based analysis of the binding of LYAR protein to the rs368698783 (G>A) polymorphic Aγ-globin gene sequences mutated in β-thalassemia.
11/2019	Development and characterization of cellular biosensors for HTS of erythroid differentiation inducers targeting the transcriptional activity of γ-globin and β-globin gene promoters.
1/2017	An Aγ-globin G->A gene polymorphism associated with β039 thalassemia globin gene and high fetal hemoglobin production.
12/2015	Development and characterization of K562 cell clones expressing BCL11A-XL: Decreased hemoglobin production with fetal hemoglobin inducers and its rescue with mithramycin.

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Lucia Carmela Cosenza Research Topics

Disease

8	Thalassemia 01/2022 - 12/2015
3	Sickle Cell Anemia (Hemoglobin S Disease) 10/2020 - 10/2019
2	Hemoglobinopathies 12/2021 - 10/2020
2	Inborn Genetic Diseases (Disease, Hereditary) 01/2017 - 04/2016
1	Stomatitis 01/2022
1	Glioma (Gliomas) 07/2019
1	Asymptomatic Diseases 01/2017
1	beta-Thalassemia (Cooley's Anemia) 04/2016
1	Leukemia 12/2015
1	B-Cell Lymphoma (Lymphoma, B Cell) 12/2015

Drug/Important Bio-Agent (IBA)

9	GlobinsIBA 01/2022 - 12/2015
7	Fetal Hemoglobin (Hemoglobin F)IBA 01/2022 - 12/2015
3	Messenger RNA (mRNA)IBA 01/2022 - 07/2019
3	Hemoglobins (Hemoglobin)IBA 12/2021 - 12/2015
3	DNA (Deoxyribonucleic Acid)IBA 01/2017 - 04/2016
1	Pharmaceutical PreparationsIBA 01/2022
1	Sirolimus (Rapamycin)FDA Link 01/2022
1	cinchonidineIBA 12/2021
1	Cinchona AlkaloidsIBA 12/2021
1	Quinidine (Chinidin)FDA LinkGeneric 12/2021
1	Small Molecule LibrariesIBA 10/2020
1	Biological ProductsIBA 10/2020
1	Proteins (Proteins, Gene)FDA Link 11/2019
1	Peptide Nucleic AcidsIBA 07/2019
1	MicroRNAs (MicroRNA)IBA 07/2019
1	Temozolomide (Temodar)FDA LinkGeneric 07/2019
1	Hydroxyurea (Hydrea)FDA LinkGeneric 01/2017
1	5' Untranslated Regions (5' UTR)IBA 01/2017

Therapy/Procedure

1	Precision Medicine 01/2022
1	Investigational Therapies (Experimental Therapy) 11/2019
1	Therapeutics 11/2019
1	Bone Marrow Transplantation (Transplantation, Bone Marrow) 04/2016